Valproat/Apilepsin/Depakine/Depakote-interakcije z zdravili

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Valproat/Apilepsin/Depakine/Depakote-interakcije z zdravili

OdgovorNapisal/-a mavrica » 12 nov 2007, 17:21

Ker se je pred kratkim odprla diskusija o možnih interakcijah valproata z drugimi zdravili, prilagam skopiran tekst o možnih interakcijah tega zdravila z raznimi drugimi zdravili, tudi aspirinom med drugim, ko je že bilo govora o tem. Tekst je z linka, ki zahteva plačljivo registracijo, tako da linka ne navajam. Upam, da bo informacija komu pomagala in upam, da ne boste imeli prevelikih težav z angleščino.

Antipsychotics
anticonvulsant effect of valproate antagonised by antipsychotics (convulsive threshold lowered) Increased risk of toxicity with myelosuppressive drugs
Aspirin
effects of valproate enhanced by aspirin
Bupropion
valproate inhibits the metabolism of bupropion Bupropion should be administered with extreme caution to patients receiving other medication known to lower the seizure threshold—see CSM advice section 4.10 and Cautions, Contra-indications and Side-effects of individual drugs
Carbamazepine
plasma concentration of valproate reduced by carbamazepine , also plasma concentration of active metabolite of carbamazepine increased
Cimetidine
metabolism of valproate inhibited by cimetidine (increased plasma concentration)
Clobazam
plasma concentration of valproate possibly increased by clobazam
Clonazepam
increased risk of side-effects when valproate given with clonazepam
Colestyramine
absorption of valproate possibly reduced by colestyramine Other drugs should be taken at least 1 hour before or 4-6 hours after colestyramine to reduce possible interference with absorption
Coumarins
valproate possibly enhances anticoagulant effect of coumarins Change in patient's clinical condition, particularly associated with liver disease, intercurrent illness, or drug administration, necessitates more frequent testing. Major changes in diet (especially involving salads and vegetables) and in alcohol consumption may also affect anticoagulant control
Diazepam
valproate possibly increases plasma concentration of diazepam
Ertapenem
plasma concentration of valproate possibly reduced by ertapenem
Erythromycin
metabolism of valproate possibly inhibited by erythromycin (increased plasma concentration) Interactions do not apply to small amounts of erythromycin used topically
Ethosuximide
valproate possibly increases plasma concentration of ethosuximide
Lamotrigine
valproate increases plasma concentration of lamotrigine
Lorazepam
valproate possibly increases plasma concentration of lorazepam
Mefloquine
anticonvulsant effect of valproate antagonised by mefloquine
Meropenem
plasma concentration of valproate reduced by meropenem
Olanzapine
increased risk of neutropenia when valproate given with olanzapine
Oxcarbazepine
valproate sometimes reduces plasma concentration of an active metabolite of oxcarbazepine
Phenobarbital
valproate increases plasma concentration of phenobarbital (also plasma concentration of valproate reduced)
Phenytoin
valproate increases or possibly decreases plasma concentration of phenytoin , also plasma concentration of valproate reduced
Primidone
valproate possibly increases plasma concentration of primidone (plasma concentration of active metabolite of primidone increased), also plasma concentration of valproate reduced
Sodium Benzoate
valproate possibly reduces effects of sodium benzoate
Sodium Phenylbutyrate
valproate possibly reduces effects of sodium phenylbutyrate
Temozolomide
valproate increases plasma concentration of temozolomide
Zidovudine
valproate possibly increases plasma concentration of zidovudine (increased risk of toxicity) Increased risk of toxicity with nephrotoxic and myelosuppressive drugs - for further details consult product literature

Antidepressants, SSRI
anticonvulsant effect of antiepileptics antagonised by SSRIs (convulsive threshold lowered)
Antidepressants, Tricyclic
anticonvulsant effect of antiepileptics antagonised by tricyclics (convulsive threshold lowered)
Antidepressants, Tricyclic (related)
anticonvulsant effect of antiepileptics possibly antagonised by tricyclic-related antidepressants (convulsive threshold lowered)
Chloroquine and Hydroxychloroquine
possible increased risk of convulsions when antiepileptics given with chloroquine and hydroxychloroquine
MAOIs
anticonvulsant effect of antiepileptics possibly antagonised by MAOIs (convulsive threshold lowered) For interactions of reversible MAO-A inhibitors (RIMAs) see Moclobemide, and for interactions of MAO-B inhibitors see Rasagiline and Selegiline; the antibacterial Linezolid is a reversible, non-selective MAO inhibitor
Mefloquine
anticonvulsant effect of antiepileptics antagonised by mefloquine
mavrica
 
Prispevkov: 36
Pridružen: 02 maj 2006, 21:51
Kraj: ljubljana

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